Next challenge: a synthetic human?

A group of researchers is calling for the next challenge in genetics: create an entirely synthetic human genome. The Human Genome Project Write (HGP-write) aims at creating a human genome from scratch, using the information available from thousands of sequenced human genomes.

Creating a DNA sequence that corresponds to a viable human being is quite an achievable challenge with existing technology. The large number of sequenced human genomes provide an excellent blueprint for that such a genome could be. Poorly understood or hard to sequence regions provide considerable challenges, but they should not be impossible to tackle. More difficult would be to create viable cell lines out of the synthesised DNA, or even viable embryos.

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As IEEE Sprectrum reports, the subject has received considerable attention in the media, namely in the NY Times. The authors of the proposal have already said that they do not intend to create synthetic humans, but only advance the state of the art in genetics research. Their objective is to understand better the human genome, by building a human (and other) genome from scratch. However, one never knows where a road leads, only where it starts from.

 

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