Writing a Human Genome from scratch: the Genome Project-write

The Genome Project-write has released a white paper, with a clear proposal of the steps and timeline that will be required to design and assemble a human genome from scratch.

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The project is a large scale project, involving a significant number of institutions, and many well-known researchers, including George Church and Jef Boeke. According to the project web page:

“Writing DNA is the future of science and medicine, and holds the promise of pulling us forward into a better future. While reading DNA code has continued to advance, our capability to write DNA code remains limited, which in turn restricts our ability to understand and manipulate biological systems. GP-write will enable scientists to move beyond observation to action, and facilitate the use of biological engineering to address many of the global problems facing humanity.”

The idea is to use existing technologies for DNA synthesis to accelerate research in a wide spectrum of life-sciences. The synthesis of human genomes may make it possible to understand the phenotypic results of specific genome sequences and will contribute to improve the quality of synthetic biology tools.

Special attention will be paid to the complex ethical, legal and social issues that are a consequence of the project.

The project has received wide coverage, in a number of news sources, including popular science sites such as Statnews and the journal Science.

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Next challenge: a synthetic human?

A group of researchers is calling for the next challenge in genetics: create an entirely synthetic human genome. The Human Genome Project Write (HGP-write) aims at creating a human genome from scratch, using the information available from thousands of sequenced human genomes.

Creating a DNA sequence that corresponds to a viable human being is quite an achievable challenge with existing technology. The large number of sequenced human genomes provide an excellent blueprint for that such a genome could be. Poorly understood or hard to sequence regions provide considerable challenges, but they should not be impossible to tackle. More difficult would be to create viable cell lines out of the synthesised DNA, or even viable embryos.

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As IEEE Sprectrum reports, the subject has received considerable attention in the media, namely in the NY Times. The authors of the proposal have already said that they do not intend to create synthetic humans, but only advance the state of the art in genetics research. Their objective is to understand better the human genome, by building a human (and other) genome from scratch. However, one never knows where a road leads, only where it starts from.